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Home - Products - Proteasome/Ubiquitin - Endogenous Metabolite - PAPA NONOate

PAPA NONOate

CAS No. 146672-58-4

PAPA NONOate( —— )

Catalog No. M36582 CAS No. 146672-58-4

PAPA NONOate is a pH-regulated NO donor.PAPA NONOate has potential antitumor activity and can be used to study diabetic wound healing disorders.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PAPA NONOate
  • Note
    Research use only, not for human use.
  • Brief Description
    PAPA NONOate is a pH-regulated NO donor.PAPA NONOate has potential antitumor activity and can be used to study diabetic wound healing disorders.
  • Description
    PAPA NONOate is a NO donor with a NO release half-life of 77 min (22-25°C). PAPA NONOate may represent a potential research for impaired wound healing in diabetes by increasing the rate of collagen synthesis at the wound site.
  • In Vitro
    PAPA NONOate (50 μM; 12 h) significantly reduces 70% caspase-3-like activity in caspase-3-overexpressing HUVEC and abolishs the induction of cell death by caspase-3.
  • In Vivo
    PAPA NONOate (100 μM in phosphate buffer) increases the rate of wound healing in rats with diabetes and wound.Animal Model:Anesthetized male Sprague-Dawley rats with streptozotocin-induced diabetes and full thickness dermal wound Dosage:100 μM Administration:Wounds received 100 μM PAPA NONOate in phosphate buffer Result:Increased the wound healing rate in test group.
  • Synonyms
    ——
  • Pathway
    Proteasome/Ubiquitin
  • Target
    Endogenous Metabolite
  • Recptor
    Endogenous Metabolite | NO Synthase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    146672-58-4
  • Formula Weight
    176.22
  • Molecular Formula
    C6H16N4O2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?H2O : 50 mg/mL (283.74 mM; Ultrasonic (<60°C)
  • SMILES
    O=NN(O)N(CCC)CCCN
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. R?ssig L, et al. Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J Biol Chem. 1999 Mar 12;274(11):6823-6.?
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